Source
Kimura R, Ueda R, Tsujimura H, Ban T, Tanaka A. Urinary D-amino acid profiles in cats with chronic kidney disease. J Vet Med Sci. 2024;86(8):855-859. doi:10.1292/jvms.24-0023
Research Note
Clinical signs of chronic kidney disease (CKD) are generally observed in International Renal Interest Society (IRIS) stages II through IV. Although CKD is incurable, early-stage treatment may slow progression.
In this study, urinary D-amino acid level measurement was assessed as a potential noninvasive method for CKD detection in cats. Urine from 11 cats with stage II CKD and 17 healthy control cats was analyzed for D-amino acid levels using chiral tandem liquid chromatography–tandem mass spectrometry. Levels of D-amino acids were significantly lower in cats with CKD compared with control cats and significantly negatively correlated with BUN and creatinine. The authors concluded that measurement of urinary D-amino acid levels may help detect stage II CKD in cats and could be a highly accurate, noninvasive method for monitoring disease.
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